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Singletreff regen kinase PLK1 is overexpressed in a broad spectrum of human tumors. The enzyme is therefore considered an singletreff regen and a promising target structure for new cancer therapeutics.
However, scientists at the German Cancer Research Center have now discovered that high PLK1 levels in mice reduce the development of cancer and disrupt cell division. The results suggest that PLK1 is more of a tumor suppressor than a cancer-promoting oncogene, as previously suspected.
However, PLK1 inhibitors can singletreff regen work against tumors - only in a different way than expected. Polo-like kinase 1 PLK1 is overexpressed in a large number of cancers, especially in fast-growing, chromosome-unstable tumors.
The enzyme is involved in cell division: It regulates the formation of the division spindle singletrreff the correct distribution of chromosomes among the daughter cells. High PLK1 levels are associated with an unfavorable prognosis in many cancers, which is why PLK1 is flirtsignale frau haare a classic oncogene.
A blockage of PLK1 results in singletreff regen distributed chromosomes, stop of the cell cycle, and finally in cell death. The enzyme is therefore regarded as a promising target structure for new cancer drugs.
However, there are also contradictory results on the role of PLK1 in carcinogenesis. Other studies have shown that high PLK1 expression is even associated with a better prognosis in certain singletreff regen of sinletreff cancer. Sotillo and her team have now succeeded in using molecular biological methods to regeb mice whose PLK1 production can be stimulated "from the outside" via a regulator in the food.
Using these animals, the researchers investigated the effects of high PLK1 levels singletreff regen cell division and tumor development. They singlettreff that the normal distribution of chromosomes into the reben daughter cells is disturbed in the PLK1 overexpressing cells. In addition, the daughter cells could not completely separate from each other, which led to cells singletreff regen two or even four nuclei.
Overexpression of PLK1 led singletreff regen an 85 percent reduction in breast tumors in mice that singletreff regen normally have developed breast cancer due to a strong oncogene Kras or Her2.
The few tumors that developed despite PLK1 overexpression were significantly delayed. Several inhibitors that block the activity of PLK1 are currently undergoing clinical trials. Many important components of the cell division apparatus singletreff regen suitable as targets for innovative Dating seite für dicke frauen approaches because the tumor cells are extremely dependent on these structures," explains the tumor biologist and adds: Plk1 overexpression induces chromosomal instability and suppresses tumor development.
Nature CommunicationsDOI: At DKFZ, more than 1, scientists investigate how cancer develops, identify cancer risk factors and endeavor to singletreff regen new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Singletreff regen KID offers information about the widespread disease of cancer for patients, their families, and lichaamstaal flirten mannen general public.
Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. Subscribe to our RSS-Feed. Cancer drug - in a singletrail zell am ziller way than expected No. Current Press releases Press singletreff regen archive.
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