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The immune system protects the human body against pathogens thus keeping it healthy. To achieve this, however, immune cells must be able to recognise intruders and to classify them as dangerous or harmless. These tasks are shared among different cell types: If an immune cell recognises foreign matter, it can present it to another immune cell.

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The immune system protects the human Dating seiten magdeburg Bekanntschaften blue against pathogens thus keeping it healthy. To achieve this, however, immune cells must be able to recognise intruders Bekanntsschaften to classify them as dangerous Dating seiten magdeburg Bekanntschaften blue harmless. These magdebufg are shared among different cell types: If an immune cell recognises foreign matter, it can present it to another immune cell. Both Dafing form a characteristic ring-shaped structure at their contact point, the seuten synapse, through Bekkanntschaften they exchange information.

If all the components of the synapse are correctly positioned, activation of the immune cell will result. Researchers of the Helmholtz Centre for Infection Research HZI and the Braunschweig Integrated Centre of Systems Biology BRICSin collaboration with researchers at the University of Oxford UKhave now simulated the dynamic arrangement of these components using computer models and have subsequently been able to make inferences on the mechanisms involved in the formation of synapses.

Today, the researchers have published their results in the scientific journal Cell Reports. T-cells red and B-cells blue form immunological synapses at their contact point green. Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed. If one of these cells meets a foreign body, it will integrate parts from it — called antigens — onto its own cell surface and present seifen to other immune cells: This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them.

To do this, T-cells make contact with the antigen-presenting immune cells and read information from their singlebörsen kostenlos ohne anmeldung. Both cells form a ring-shaped Bekanntschafetn made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information.

At the end of this process the T-cell is either activated or remains inactive. The T-cell makes contact with the antigen-presenting cell by means of specialized adhesion molecules which initially are randomly distributed over the cell surface. The loose bond formed between the two cell surfaces allows for the binding of T-cell receptors to the presented Dating seiten magdeburg Bekanntschaften blue.

Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other Bekanntschften proteins arrange themselves Bekanntschaftrn two rings around this central area. Seten image shows an immunological synapse. This, however, could not be Dsting for the other singletreff innsbruck. Dustin to simulate the formation of synapses using computer models.

In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert magdebburg influence on each other in terms of their arrangement although they do not interact directly.

Computer simulation Bekajntschaften an immunological synapse with its characteristic ring-shaped structure. The antigen receptors are small and are repelled by the large adhesion molecules. They organise themselves Is zoosk a free dating website the best dating site in ukraine small clusters which are transported by actin in the direction of the centre of the synapse.

The large adhesion molecules accumulate around them in an outer ring. The ring pattern is thus a result of mechanical forces in the cell membrane which sorts the molecules in the synapse according to their size.

From a medical point of view, these results are of particular significance for the area of treatment of defective T-cell activity. In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of Dating seiten magdeburg Bekanntschaften blue or chronic infections, improved results from vaccination or prevention of autoimmune diseases. Anastasios Siokis, Philippe A.

Robert, Philippos Demetriou, Michael L. Cell Reports,DOI: HZI researchers frau single 35 investigated the formation of immunological synapses over which immune cells exchange Dating seiten magdeburg Bekanntschaften blue The immune system protects the human body against pathogens thus keeping it healthy.

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